The N3 in Bedfordview, between Van Buuren Road and the M2 Geldenhuis Interchange, was closed on Wednesday morning after a bridge collapsed.
The Cydonia Bridge pedestrian caved in, in the early hours of the morning, after a truck crashed into it.
The City of Ekurhuleni said four vehicles, three trucks and a sedan crashed into the concrete bridge which was lying across both the north and south bounds of the freeway.
No one was killed, but several people were injured, one of them critically.
A female passenger was trapped for two hours inside the wreckage of the truck that had crashed into the bridge.
A total of five patients – among them a seven-year-old girl – were accounted for from all vehicles.
“(When Emergency Services) arrived, three patients from one truck were still trapped inside the cab and two in other vehicles escaped with minor injuries,” the City of Ekurhuleni said in a statement.
“Rescue teams had to use Jaws of life to rescue those trapped inside the cab of one truck. The driver and a seven-year-old girl were transported to Bertha Gxowa hospital in Germiston in stable conditions, while the adult female passenger was airlifted to Linmed hospital in critical condition.”
Traffic is being diverted and motorists have been urged to use alternate routes to avoid delays.
Two people were killed in October 2015 when a pedestrian bridge at the M1 Grayston Road offramp in Sandton collapsed onto the highway.
“The freeway is still closed to traffic in both directions and motorists are advised to avoid using the N3 freeway through Geldenhuys interchange as it will take time to clear up the debris,” said the City.